Mechanism of WPW syndrome

WPW Syndrome

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What is WPW syndrome?

WPW syndrome or Wolff-Parkinson-White syndrome is a heart rhythm disorder characterized by an extra electrical pathway in the heart. This congenital condition can cause abnormal heart rhythms, resulting in palpitations and, rarely, sudden death. It’s typically diagnosed in young adults but can occur at any age.

A normal heartbeat begins with an electrical signal from the sinus node. This signal first spreads to the atria, then slowly passes through the AV node to reach the ventricles. In WPW syndrome, there is an additional conduction pathway. The electrical signal reaches the ventricles through both the AV node and this abnormal pathway, disrupting the heart’s normal electrical activity.

Mechanism of WPW syndrome
Mechanism of WPW syndrome

You can find detailed information about WPW syndrome in the video below.

Why Do Palpitations Occur in WPW Syndrome?

People with WPW syndrome have an abnormal extra pathway in their heart. The electrical signal creates a circuit using both the abnormal extra pathway and the normal pathway (AV node). During this process, each circuit causes a heartbeat, and palpitations begin. These palpitations that start, continue for a while, and then stop are called paroxysmal tachycardia. Some people may have an extra conduction pathway but experience no symptoms. This accessory pathway may need to be tested through an electrophysiological study. Accessory pathways with weak conduction properties may not cause palpitations and might not pose a risk for the patient.

What are the Symptoms of WPW Syndrome?

People with WPW syndrome may experience palpitations along with chest pain, shortness of breath, dizziness, and fainting symptoms. In rare cases, Wolff-Parkinson-White syndrome can be life-threatening. This is due to the transmission of a rhythm disorder called atrial fibrillation through the extra conduction pathway to the ventricle, causing the heart rate to increase significantly.

How is WPW Syndrome Diagnosed?

WPW syndrome is diagnosed through a test called ECG (electrocardiogram). Sometimes, a 24-hour ECG recording called Holter monitoring can also help with diagnosis. The ECG can show where this abnormal pathway is located in the heart. If your doctor plans to perform an ablation treatment, they can predict where the abnormal pathway is before the procedure.

How is WPW Syndrome Treated?

WPW syndrome treatment is addressed in two phases: stopping the palpitations and eliminating the disease. To stop palpitations in WPW treatment, patients can perform maneuvers such as coughing and straining (may be effective in some patients). Various medications can be used in the hospital, or sometimes electrical shock (cardioversion) may be applied. A procedure called “ablation” is used to eliminate the disease. WPW ablation is performed using either cold or hot energy. The abnormal pathway is located and rendered non-functional.

WPW ablation has a high success rate. During the procedure, catheters are sent to the heart through veins or arteries in the groin. The heart’s electrical signal is evaluated, and the location of the abnormal area is determined. The abnormal area is burned or frozen using special catheters. This method can completely eliminate the disease, and the chance of recurrence is low.

FREQUENTLY ASKED QUESTIONS

Is WPW syndrome dangerous? While WPW syndrome is usually benign, it can sometimes lead to serious arrhythmias and, rarely, sudden cardiac death.

Does WPW syndrome affect pregnancy? WPW syndrome generally doesn’t cause significant problems during pregnancy but requires close monitoring.

What is the success rate of WPW ablation? The success rate of WPW ablation is approximately 95%.

Can WPW syndrome be inherited? Yes, there is a genetic component to WPW syndrome. Family members may need to be screened.

At what age is WPW syndrome typically diagnosed? While it can be diagnosed at any age, it’s most commonly identified in young adults between 20-40 years old.

Can someone with WPW syndrome exercise? Most people with WPW can exercise, but should be evaluated by a cardiologist first to determine safe activity levels.

What triggers WPW episodes? Common triggers include:

  • Caffeine
  • Alcohol
  • Stress
  • Physical exertion
  • Certain medications
  • Lack of sleep

How long does WPW ablation recovery take? Most patients return to normal activities within a few days to a week after the procedure.

Are there any lifestyle restrictions with WPW? After successful treatment, most patients can lead normal lives without restrictions.

Can WPW reoccur after ablation? While rare, recurrence is possible in about 5% of cases.

Reference: WPW

Update: Oct 25, 2024